Protective Effect of Leucoverin on Cypermethrin- Induced Toxicity in Mice
نویسندگان
چکیده
Effects of Cypermethrin and their reversal by Leucoverin following oral administration were evaluated in mice. Mature male swiss mice were orally administered cypermethrin (15 mg/kg body wt), leucoverin (50mg/kg body wt) or both daily for 4 weeks. At the end of fourth week, hematological & serum biochemical were studied. Subchronic exposure to cypermethrin significantly reduced, when the co-contaminant leucoverin administration restored the changes in the body weight, hematological parameters, and serum biochemical indices and significantly increased the antibody titer, and cell mediated immunity. These results suggest that concurrent leucoverin treatment has a beneficial role in mitigating adverse effects of cypermethrin.
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